A.For a two-compartment-body model drug, the parameter alpha is always larger than the parameter beta.
B.The volume of distribution during the beta phase is larger than that of the volume of distribution at steady state.
C.We often use one compartment model pharmacokinetics, although a number of drugs show a distinct distribution phase, especially if the higher concentrations during the alpha phase are not related to toxicity.
D.Assume that a low extraction drug, showing a two compartment model behavior is metabolized via enzymes that are subject to enzyme induction by other drugs. The volume of distribution during the beta phase might be decreased by such enzyme-inducers

A.Cytochrome P450
B.UDP-glucoronyltransferase
C.Sulfotransferase
D.Epoxide hydrolase

A.Glucuronidation
B.Methylation
C.Sulfation
D.Glutathione conjugation

 The two lines differ in only One of the subsequent parameters (Vd, Dose, clearance). Please circle the parameter they differ in

 A.Dose
 B.Vd
C.Clearance

A.nonionized and hydrophilic
B.ionized and hydrophilic
C.nonionized and lipophilic
D.ionized and lipophilic

A.Lower maintenance dose and longer dosing interval
B.Same maintenance dose and shorter interval
C.Increase loading dose
D.Higher maintenace dose and same interval

1 For a two-compartment-body model drug, the rate constant describing the elimination of the drug from the central compartment (quantifying urinary and/or metabolic elimination) does not change with time after drug administration

2 The bi-exponential concentration time-profile, is due to the fact that clearance values change over time.

3 The two-compartmental behavior of a number of drugs is not the reason why peak-levels are often taken some time after stop of the drug administration

4 Let us assume that the toxicity of aminoglycosides is related to the drug-concentration in a deep peripheral compartment into which the drug enters very slowly and from which the drug leaves very slowly. Drug toxicity will be observed immediately after an iv bolus of this aminoglycoside.

The correct statement(s) is (are):

A.1
B.2 and 3
C.1 and 3
D.1 and 4
E.1,2 and 3

A.Cytochrome P450
B.Sulfotransferase
C.Quinone reductase
D.Alcohol dehydrogenase

A.Methylation
B.Glucuronidation
C.Acetylation
D.Hydroxylation

A.Ethanol-based induction of a P-450 isoform responsible for the metabolism of acetaminophen
B.Ethanol-based inhibition of a P-450 isoform responsible for the metabolism of acetaminophen
C.Acetaminophen-based induction of a P-450 isoform responsible for the metabolism of ethanol
D.Acetaminophen-based inhibition of a P-450 isoform responsible for the metabolism of ethanol